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Evidence is increasing that most addiction without exception is related to difficulty with the brain's reward center, specially the mesolimbic system. This part of the problem regulates reward responses in establishing food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both whenever they malfunction and whenever they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to shed pounds can be very effective you can find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people that go through it you ought to err assisting caution and allow the FDA do its job and demand some research be done so that the public knows the side effects and risks of the medications before we take them. Keep in mind that drug companies come in business to generate income and that they would say anything to keep people on their medications.

Researchers found out that participants taking this drug for any year, lost weight within a month and have kept the load off during the entire 56 weeks with the study. Contrave is often a combination of the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which are made up of multiple active ingredient, that might make them more effective and safer.

Combo-pilling may be the newest fad or even better the newest in the future under scrutiny and for that reason it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular is the fact that by right now there are not any long term prescription weight loss supplements that have been licensed by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug could also raise blood pressure level and heartbeat, and really should not be used in people with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure levels and heartrate and must stop used in patients with uncontrolled high blood pressure, along with by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients having a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients for the increased risk of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking.

"There were no warning signs of depression or suicidal thoughts in trial participants," said Fujioka.

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