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Naltrexone is approved to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so that as an aid to stopping smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle including a reduced-calorie dieting and exercise, Contrave provides another treatment choice for chronic weight management for people who are obese or are overweight and also have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular physical exercise. Results from a clinical study that enrolled patients without diabetes demonstrated that patients had a normal weight loss of 4.1% as opposed to participants who have been given placebos) within a 12- month period, while an outside study involving patients with diabetes had a typical weight loss of 2% over treatment with placebo at one full year. Using two separate drugs to shed pounds can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight-loss and the individuals who go through it you need to err assisting caution and permit the FDA do its job and demand some investigation be done so that the public knows the side effects and hazards of the medications before we bring them. Keep in mind that drug companies are in business to generate money and that they would say anything to keep people on his or her medications. Researchers found that participants using this drug to get a year, dropped excess weight within a month and have kept the load off during the entire 56 weeks of the study. Contrave is often a combination of the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which can be made up of many active ingredient, which may make them more efficient and safer. Combo-pilling could be the newest fad or also the newest in the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular is the fact that since right now there are no long term prescription slimming capsules that have been authorized by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be approved by the FDA. Seizures certainly are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug also can raise blood pressure level and pulse rate, and mustn't be used in people who have a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise hypertension and heartbeat and must not used in patients with uncontrolled high blood pressure levels, and also by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients using a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients towards the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking. To conserve the most current articles from Wendi, the Indiana Addiction Recovery Examiner, click on the subscribe link towards the top of the page to obtain email notification when new content is published. Please leave a comment for almost any article.
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